Query   'TRFH domain'  matched   5 Records

Record No : 1

Instance ID11032
Regular Expression[FY]xLxP
Motif InstanceFTLKP
Bait Uniprot AccessionQ96BK5
Bait Uniprot IdentifierPINX1_HUMAN
Bait Gene NamePINX1
Bait OrganismHomo sapiens (Human)
Sequence Position289-293
Critical ResiduesP3
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)ITC
Interaction ID21032
Interacting DomainTRFH domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)18202258
CommentsThe telomeric repeat binding factor (TRF) homology (TRFH) domain of human Telomeric repeat-binding factor 1 (TERF1/PIN2/TRF1) recognizes and directly interacts with the [Y/F]XL motif in human PIN2/TERF1-interacting telomerase inhibitor 1 (PINX1) and regulates telomere maintenance

Record No : 2

Instance ID11033
Regular Expression[FY]xLxP
Motif InstanceFNLAP
Bait Uniprot AccessionQ9BSI4
Bait Uniprot IdentifierTINF2_HUMAN
Bait Gene NameTINF2
Bait OrganismHomo sapiens (Human)
Sequence Position258-262
Critical ResiduesP1; P3
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutation analysis; ITC; Co-IP; X-ray crystallography
Interaction ID21033
Interacting DomainTRFH domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)18202258
CommentsThe telomeric repeat binding factor (TRF) homology (TRFH) domain of human Telomeric repeat-binding factor 1 (TERF1/PIN2/TRF1) recognizes and directly interacts with the [Y/F]XL motif in human TERF1-interacting nuclear factor 2 (TINF2/TIN2) and regulates telomere maintenance

Record No : 3

Instance ID11034
Regular Expression[FY]xLxP
Motif InstanceYLLTP
Bait Uniprot AccessionQ9H816
Bait Uniprot IdentifierDCR1B_HUMAN
Bait Gene NameDCLRE1B
Bait OrganismHomo sapiens (Human)
Sequence Position504-508
Critical ResiduesP1; P3; P5
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)X-ray crystallography; ITC; Co-IP; Mutation analysis
Interaction ID21034
Interacting DomainTRFH domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)18202258
CommentsThe telomeric repeat binding factor (TRF) homology (TRFH) domain of human Telomeric repeat-binding factor 2 (TERF2/TRF2) recognizes and directly interacts with the [Y/F]XL motif in human 5' exonuclease Apollo/ DNA cross-link repair 1B protein (DCLRE1B) and regulates telomere maintenance

Record No : 4

Instance ID11978
Regular Expression[YF]xLxP
Motif InstanceYNLKP
Bait Uniprot AccessionQ96QC0
Bait Uniprot IdentifierPP1RA_HUMAN
Bait Gene NamePPP1R10
Bait OrganismHomo sapiens (Human)
Sequence Position236-240
Critical ResiduesP1; P3
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutational analysis
Interaction ID21978
Interacting DomainTRFH domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)19287395
CommentsThe telomeric repeat binding factor (TRF) homology (TRFH) domain of human Telomeric repeat-binding factor 2 (TERF2/TRF2) recognizes and directly interacts with the [Y/F]XL motif in human Phosphatase 1 regulatory subunit 10 (PPP1R10/PNUTS) and regulates telomere maintenance

Record No : 5

Instance ID11979
Regular Expression[YF]xLxP
Motif InstanceYRLSP
Bait Uniprot AccessionQ8NEM0
Bait Uniprot IdentifierMCPH1_HUMAN
Bait Gene NameMCPH1
Bait OrganismHomo sapiens (Human)
Sequence Position330-334
Critical ResiduesP1; P3
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutational analysis
Interaction ID21979
Interacting DomainTRFH domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)19287395
CommentsThe telomeric repeat binding factor (TRF) homology (TRFH) domain of human Telomeric repeat-binding factor 2 (TERF2/TRF2) recognizes and directly interacts with the [Y/F]XL motif in human Microcephalin (MCPH1) and regulates telomere maintenance


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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)